利培酮、氯丙嗪治疗精神分裂症阴性症状对照研究

A Comparative Study of Risperdal and Chlorpromazine in the Treatment of the Negative Symptoms of Schizophrenia

目的 :评价利培酮、氯丙嗪对精神分裂症阴性症状的疗效。方法 :采用前瞻性单盲对照研究方法 ,以阴性症状评定量表 (SANS)的得分结果来评价。结果 :利培酮组治疗前后SANS总分及各分量表的综合评分均显著降低 (P <0 .0 5或 0 .0 1)而氯丙嗪组降低不明显。结论 :利培酮对阴性症状的疗效显著优于氯丙嗪。

Objective:To compare the therapeutic effect of risperdal and chlorpromazine on the negative symptoms of schizophrenia. Method:A signle blind prospective study in which 32 schizophrenic patients with negative symptoms received risperdal (n=17) and chlorpromazine (n=15) respectively. The scoring results of SANS were used for the evaluation of negative symptoms. Results:There were the obvious reductions in the total score of SANS or the comprehensive score of several subgroups (P<0.05 or <0.01). The total SANS score and five SANS factors were more reduced significantly (P<0.01) in risperdal treated patients than chlorpromazine treated subjects. Conclusion:The therapy effect of risperdal on the negative symptoms of schizophrenia is superior to chlorpromazine.