摘要
目的 :观察小剂量昂丹司琼联合止呕方案对化疗所致恶心呕吐的疗效及不良反应。方法 :采用自身对照方法 ,第 1周期化疗时单用推荐剂量的昂丹司琼止呕 (单用组 ) ;第 2周期用小剂量昂丹司琼联合甲氧氯普胺、地塞米松、地西泮、异丙嗪止呕 (联合组 )。结果 :单用组有效率 91.7% ,联用组 90 .0 % (P >0 .0 5 ) ;化疗后两组间逐日比较止呕疗效差异不显著 (P >0 .0 5 )。结论 :小剂量昂丹司琼联合止呕方案与单用推荐剂量昂丹司琼止呕效果相近 ,不良反应少 ,医疗费用下降 2 3。
Objective:To observe the efficacy and toxicity of combined antiemetic regimen including low dose ondansetron on chemotherapy induced nausea and vomiting. Method:The self controlled method was used. Every patient received recommended dose of single ondansetron during first chemotherapy cycle (single group), and low dose ondansetron combined with metoclopramide, dexamethasome, diazepam, and promethazine (combined group) during second chemotherapy cycle. Results:The effective rate of single group and combined group were 91.7% and 90.0%, respectively (P>0.05). The difference was not significant in the antiemetic efficacy between two groups. Conclusion:The efficacy of the combined with antiemitic regimen including low dose ondansetron was similar to that of the recommended dose ondansetron with lower toxicity. The medical cost of every patient was saved about two thirds.
出处
《医药导报》
CAS
2000年第4期341-342,共2页
Herald of Medicine
关键词
昂丹司琼
甲氧氯普胺
地塞米松
联合止呕
肿瘤
Chemotherapy Nausea and vomiting Ondansetron Combined antiemetic regimen