苯磺酸氨氯地平联合贝那普利治疗高血压的疗效分析

The Analysis on the Effect of Hypertension Treated by Amlodipine Besylate with Benazepril

目的:探讨分析苯磺酸氨氯地平联合贝那普利治疗高血压病的临床疗效。方法:选取2010年10月-2012年9月在笔者所在医院内科治疗的高血压病患者112例,随机分为观察组(n=56)和对照组(n=56),对照组给予苯磺酸氨氯地平片口服治疗,观察组给予苯磺酸氨氯地平片口服治疗的基础上加服贝那普利。连续治疗8周后,比较两组患者治疗后疗效、不良反应发生率及治疗前后血压变化情况。结果:治疗后观察组总有效率为91.1%,血压平均值为(126±13)/(81±7)mmHg,不良反应发生率为3.6%;对照组总有效率为73.2%,血压平均值为(137±14)/(92±10)mmHg,不良反应发生率为12.5%;两组总有效率、血压平均值及不良反应发生率比较差异具有统计学意义(P<0.05),两组患者治疗前后的血压变化比较差异亦具有统计学意义(P<0.05)。结论:苯磺酸氨氯地平与贝那普利联合治疗高血压,取得单用氨氯地平未能达到的临床疗效,且不良反应比较少,适合在临床上广泛推广运用。

Objective：To explore and analysis on the effect of hypertension treated by amlodipine besylate with benazepril.Method：Selected 112 hypertensive patients who were treated in internal medicine of our hospital from October in 2010 to September in 2012,and randomly divided them into two groups. The control group（n=56）：patients were treated by oral therapy with amlodipine besylate tablets.The observation group（n=56）：patients were treated by oral therapy with amlodipine besylate tablets plus benazepril.After 8-weeks continuous treatment,Curative effects the incidence rate of adverse reaction,the changes of blood pressure before and after treatment were compared between the two groups after treatment.Result：After treatment, the total efficiency of the observation group was 91.1%,the average value of blood pressure was（126±13）/（81±7）mm Hg,the incidence of adverse reaction was 3.6%;the total efficiency of the observation group was 73.2%,the average value of blood pressure was（137±14）/（92±10）mm Hg, the incidence of adverse reaction was 12.5%;made a comparison of the total efficiency of two groups,blood pressure mean value and the incidence of adverse reactions were statistically significant（P 0.05）,made a comparison of the blood pressure changes before and after treatment,it was statistically significant（P 0.05）. Conclusion：For the treatment of the hypertension,the therapy of amlodipine besylate with benazepril get the clinical effects the amlodipine only fail to do with relatively less adverse reaction. So the therapy of hypertension treated by amlodipine besylate with benazepril is suitable for the extensive popularization in clinical application.