胰岛素泵强化治疗对不同体重指数初诊2型糖尿病胰岛β细胞功能、胰岛素抵抗及长期缓解的临床研究

The Clinical Research of Insulin Pump Intensive Therapy in β Cell Function of Different Body Mass Index in Patients with Type 2 Diabetes,Insulin Resistance and Long-term Remission

目的:观察胰岛素泵强化治疗对不同体重指数初诊2型糖尿病胰岛β细胞功能、胰岛素抵抗的影响。方法:将本院收诊的2型糖尿病患者按体重指数分成两组,肥胖组和正常组。所有患者均采用胰岛素泵进行强化治疗,分别于治疗前、治疗2周后、治疗18个月后对胰岛β细胞功能、胰岛素抵抗进行分析。结果:肥胖组患者治疗前后HOMA-β、HOMA-IR均显著高于正常组(P<0.05);治疗2周后,两组患者的HOMA-β、HOMA-IR与疗效基线值相比均显著下降(P<0.05);18个月后随访结果发现,两组患者的HOMA-β、HOMA-IR与疗效基线值相比仍显著下降(P<0.05)。结论:胰岛素泵强化治疗对不同体重指数初诊2型糖尿病胰岛β细胞功能、胰岛素抵抗均有改善作用,而且具有长期缓解作用。

Objective：To observe the effect of insulin pump intensive therapy in βcell function of different body mass index in patients with type 2 diabetes,insulin resistance and long-term remission. Method：Patients with type 2 diabetes in our hospital were divided into two groups according to body mass index：the obesity group and normal group. All patients were treated with insulin pump intensive treatment. 2 weeks before and after treatment, 18 months after treatment,theβcell function and insulin resistance were taken for analysis. Result：The HOMA-β,HOMA-IR in the obesity group before and after treatment in patients were significantly higher than those in the normal group（P 0.05）.After 2 weeks of treatment,two groups of patients with HOMA-β,HOMA-IR and efficacy compared to baseline values were significantly decreased（P 0.05）;follow-up results after 18 months, patients in the two group,HOMA-β HOMA-IR and efficacy compared to baseline values were significantly decreased（P 0.05）.Conclusion：Insulin pump therapy in the treatment of different body mass index in patients has the improving function with newly diagnosed type 2 diabetes isletβcell function, insulin resistance,also has the effect of long-term remission.