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血管紧张素受体阻滞剂治疗老年冠心病的有效性及安全性观察 被引量:2

The Study of the Efficacy and Safety of Angiogenesis Receptor Blockers in the Treatment of Senile Coronary Heart Disease
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摘要 目的:探讨血管紧张素受体阻滞剂治疗老年冠心病的临床疗效及安全性。方法:回顾性分析本院收治的120例老年冠心病患者的临床资料,按照治疗方法分为治疗组和对照组各60例,其中治疗组患者采用血管紧张素受体阻滞剂厄贝沙坦进行治疗,对照组患者采用血管紧张素转换酶抑制剂(ACEI)卡托普利进行治疗,比较两组患者的临床疗效和不良反应发生情况。结果:治疗6个月后,治疗组患者心绞痛11例,心律失常8例,心力衰竭4例,死亡3例;对照组患者心绞痛14例,心律失常11例,心力衰竭7例,死亡4例,除死亡率外其他比较差异均有统计学意义(P<0.05);治疗组患者的不良反应发生率为15.00%,显著高于对照组的3.33%,差异有统计学意义(P<0.05)。结论:血管紧张素阻滞剂治疗老年冠心病患者临床疗效显著,安全性高。 Objective:To investigate the clinical efficacy and safety of angiogenesis receptor blockers in treatment of senile coronary heart disease. Method:The clinical data of 120 cases of elderly patients with coronary heart disease in our hospital were taken for retrospective analysis.According to the treatment methods,the subjects were divided into the treatment group and the control group of 60 cases,the treatment group was treated with angiogenesis receptor blocker irbesartan treatment,and the control group was treated with vascular compact Zhang Su converting enzyme inhibitor(ACEI)captopril treatment.The clinical efficacy and the incidence of adverse reactions were compared.Result:After 6 months of treatment,the patients in the treatment group of 11 cases of angina pectoris,arrhythmia in 8 cases,4 cases of heart failure,3 cases of death;patients in the control group of 14 cases of angina pectoris,arrhythmia in 11 cases,7 cases of heart failure,4 cases died,in addition to the mortality of comparative difference were statistically significant (P 0.05);the incidence rate of adverse reaction was 15%,higher than the control group of 3.33%,with a statistically significant difference(P 0.05). Conclusion:The clinical efficacy of angiogenesis blockers therapeutic in the treatment of elderly patients with coronary heart disease is significant,and with high security.
出处 《中国医学创新》 CAS 2013年第22期61-62,共2页 Medical Innovation of China
关键词 血管紧张素受体阻滞剂 老年冠心病 厄贝沙坦 卡托普利 Angiotensin receptor blockers Coronary heart disease in the elderly Irbesartan Captopril
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