他克莫司延缓移植肾功能衰竭进程的临床研究

Clinical study on the course delay of grafted renal function failure by FK506

目的 观察他克莫司 (FK5 0 6 )延缓慢性移植肾功能衰竭进程的有效性及安全性。方法 选择肾移植术后肾功能异常 ,并经病理证实为慢性排斥反应者 ,将原先以环孢素A (CsA)为基础的免疫抑制方案切换成FK5 0 6为主的免疫抑制方案 ,FK5 0 6起始剂量为 0 .15mg·kg-1·d-1。结果 10例肾移植受者在换用FK5 0 6治疗后 ,血胆固醇水平和血压明显降低 ,用于控制高血压的药物明显减少 ,血肌酐水平明显降低 ,肾小球滤过率得到明显改善。结论 FK5 0 6对延缓移植肾慢性排斥引起的肾功能衰竭的进程是安全有效的。

Objectives To study the feasibilty and safety of tacrolimus delaying the course of the grafted renal function failure. Methods The patients with abnormal grafted renal function after operation and chronic renal allograft nephropathy proved pathologically were collected. A cyclosporine-based regimen was converted to a tacrolimus-based regimen. The initial dose of tacrolimus was 0.15 *!mg·kg -1 ·d -1 . Results All of the 10 patients had obvious decreases of blood cholesterol, blood creatinine level and high blood pressure after conversion to tacrolimus therapy. The number of antihypertensive drugs were significantly deceased. The GRF was significantly improved. Conclusions Conversion from cyclosporine-based regimen to tacrolimus-based regimen was an effective and safe alternative for delaying the course of renal function induced by chronic rejection of the allograft.