灸药结合治疗虚性小儿哮喘非急性发作期的临床疗效及对IgE、EOS、LTE_4含量的影响

Clinical Effects and Mechanism Research of Treatment of Deficient Children Asthma in Non-acute Onset Stage by Moxibustion Medication Combined

目的比较艾条温和灸、灸药结合、中药治疗虚性非急性发作期小儿哮喘患者的临床疗效观察,探讨灸药结合治疗虚性小儿哮喘的临床疗效及其可能的作用机理。方法 90例患儿按病情分层抽样的实验设计原则分为艾灸组、灸药结合组和中药组,每组各30例。艾灸组采用单纯艾条温和灸,每穴灸10 min,每日1次。中药组以口服平喘方为主,每日1剂,2～3次温服。灸药组的艾灸方法及穴位同艾灸组,中药处方及服用方法与中药组相同。疗程均为2个月。分别于治疗前、后各记录1次疗效指标,检测血清总免疫球蛋白E(IgE)含量、外周血嗜酸性粒细胞(EOS)直接计数、尿白三烯E4水平。结果灸药组的临床总有效率明显优于其他2组(P<0.05)。3种疗法均能有效地降低患儿血清总IgE含量、外周血EOS直接计数及尿LTE4含量,其中以灸药结合组效果最佳。结论单纯艾条温和灸及口服中药治疗虚性小儿哮喘非急性发作期均有较好的疗效,而艾条温和灸与中药结合运用,临床效果则更突出。

Objective： To observe the clinical effect of deficient children asthma in non-acute phase treated by the moxa stick mild-ward moxibustion（MWM）,the moxibustion medication（MM） combined and the Chinese medicine and to explore the clinical effect and the effective mechanism of moxibustion medication combined.Methods： 90 cases were divided into 3 groups at experimental design principle of stratifily sampling by the condition of asthma such as the MWM group,the MM combined group and the Chinese medicine group with 30 cases in each group.The MWM group was only given moxa stick mild-ward moxibustion with 10 minutes every acupoint each time.The Chinese medicine group was only taken orally Pingchuan Decoction with one dose every day.The MM combined group was given the same moxbustion methods in the MWM group.The treatment of each group was lasted 2 months.Then the effect guideline and determine the levels of IgE,EOS and LTE4 were observed respectively before and after therapy.Results： The total effective rate of the MM combined group was higher obviously than that in other groups.Levels including IgE,EOS and LTE4 in 3 groups were imprvoed significantly.Moreover,the improvement of the MM combined group was the best of these groups.Conclusion： The results of research shows that the effect of MWM or Chinese medicine treating deficient children asthma in nonacute onset stage is valid.The MM combined is the validest of all.