脑胶质瘤组织中P16MTS1基因缺失研究

P16/MTS1 gene deletion in gliomata

目的 探讨人脑胶质瘤组织中多重肿瘤抑制基因 (P16 MTS1)异常。方法 用PCR方法扩增P16基因序列。结果 5 0例脑胶质瘤患者组织中P16基因纯合性缺失 16例 ,缺失率为 32 % ,以胶质瘤Ⅲ～Ⅳ级缺失率较高 (5 7.8% )。结论 P16

Objective To investigate P16/MTS1 gene deletion in human gliomata using PCR.Methods P16 gene sequence was increased by using PCR.Results It was found that 16 cases of P16 gene deletion out of 50 cases of human gliomata.The deletion rate of P16 gene was 32%.The deletion rate was high in Ⅲ～Ⅳ grades gliomata(57.8%).Conclusion P16/MTS1 gene deletion may be related to occurrence and development of human gliomata.