咬合力增强对大鼠牙周组织白细胞介素-6表达影响的研究

Effect of increased bite force on the expression of IL-6 in rat periodontium

目的：检测咬合力在正常及增强状态下，大鼠牙周细胞ＩＬ－６的动态表达，初探ＩＬ－６在牙周组织改建中作用的分子机别。方法：采用免疫组化的方法，观察牙周形态变化以及牙周组织中ＩＬ－６蛋白表达。结果：咬合力增强引起牙周膜增宽、牙槽骨新骨形成。牙周细胞中ＩＬ－６表达较正常咬合力时明显增强。结论：咬合力增强，促使牙周组织产生ＩＬ－６明显增多，诱发了破骨功能；同时，还激活了成骨功能。

To study the expression of Il-6 in rat periodontal cells under normal and increased bite force. Methods: Immunohistochemistry technique was applied to study the morphology of periodontium and the expression of IL-6 protein under normal and increased bite force. Results: Under the increased bite force, periodontal ligament width was enlarged and new bone was formed in alveolar the expression of IL-6 increased apparently in periodontal cells. Conclusion: Increased bite force may induce the expression of IL-6 in periodontium. The morphologic change in periodontium and alveolar may be related to IL-6 expression.