胃康复冲剂对胃癌前病变脾虚证胃粘膜超微结构的影响

Effect of Weikangfu Granule on Ultrastructure of Gastric Mucosa in Patients of Precancerosis with Spleen Deficiency Syndrome

目的 :观察胃康复冲剂对胃粘膜组织超微结构的影响。方法 :应用胃康复冲剂治疗 61例脾虚证胃粘膜肠上皮化生 (IM )和不典型增生 (ATP)患者 ,治疗前后均作胃镜检查 ,取胃窦部粘膜作组织病理和超微结构检查。结果 :脾气虚证与脾阳虚证病理疗效优于脾阴虚证和脾虚气滞证 (P <0 0 5,P <0 0 1) ;4组脾虚证胃窦部病灶区组织病理、肠化生亚型和非病灶区粘膜超微结构中的“背景病变” ,在治疗后均有改善 ,趋向接近于健康对照组。结论 :胃康复冲剂是通过改善体内生物活性物质间的量比平衡关系 ,以维护机体内环境适应性调节机制 ,促进胃窦部粘膜超微结构正常化 ,而治愈临床症状 ,逆转IM和ATP的。

To observe the effect of Weikangfu Granule (WKFG) on the ultrastructure of gastric mucosa. Methods: WKFG was used to treat 61 patients with gastric mucosa intestinal metaplasia or atypical proliferation, and histopathological and ultrastructural examination on gastric mucosa of antral region obtained through gastroscopy were conducted before and after treatment. Results: After treatment, the histopathology and intestinal metaplasia subset of antral focal region, and the background lesion in ultrastructure of the mucosa in the nonfocal region were all improved in the 4 groups, The effects of Spleen-Qi Deficiency syndrome group and Spleen-Yang Deficiency group were superior to Ying-Deficiency group as well as Spleen-Deficiency and Qi-Stagnation group (P<0 05, P<0 01), and approached to those in the healthy control group. Conclusion: WKFG improves the quantitative balance of internal bioactive substances to maintain the homeostasis, promotes the ultrastructural normalization of mucosa so as to cure the clinical symptoms and reverse the intestinal metaplasia and atypical proliferation of mucosa.