胃腺癌组织中血管内皮生长因子的表达与微血管密度的关系

Relationship of vascular endothelial factor and microvessel density in gastric carcinoma tissue

为探讨胃癌组织中血管内皮生长因子(Vascular endothelial growth factor VEGF)及微血管密度(Microvessel density MVD)的关系，本文应用免疫组化S-P法对40例胃癌及20例正常胃组织中VEGF及MVD作了检测。结果表明：1、正常胃组织中VEGF表达全部阴性。胃癌组织中VEGF阳性表达率为62.5%，VEGF的表达与细胞组织学分级及淋巴结转移有显著差异(P<0.05)。2、在胃癌组织中VEGF的阳性表达和MVD值高低与有无淋巴结转移差异显著(P<0.05)，呈正相关(P<0.05)。而和细胞组织学分级呈负相关(P<0.05)，VEGF的阳性表达以及MVD值，随着胃癌分化程度的降低而增高。以上结果提示，VEGF可引起瘤内MVD增多，促进肿瘤的生长和转移。检测VEGF表达强度，可以作为判定胃癌转移潜能及评价预后的指标。

Objective: To discuss the expression of vascular endothelial growth factor (VEGF) and microvessel density (MVD) in gastric carcinoma and their relations. Method: We detected the expression of VEGF and MVD by immunohistochemical S-P method in 40 cases of gastric carcinoma and 20 cases of normal gastric tissues respectively. Results: 1. In normal gastric tissues, there was no VEGF expression. In gastric carcinoma tissues, the VEGF experession was 62.5 percent. There was obvious difference between the VEGF expression and lymphnode metastasis and histopathologic grade (P<0.05). 2. The expression of VEGF and MVD in gastric carcinoma tissues had a dramatic difference (P<0.05) and positive correlation (P<0.05) but a negative relation to cyto-histopathologic grade (P<0.05). Conclusion: The detection of VEGF expression rate can be used as a speical method to determine the prognoses of gastric carcinoma.