参芪复方加减治疗2型糖尿病大血管病变患者57例临床观察

Clinical Observation on Modified Shenqi Compound for 57 Cases of Macrovascular Disease in Type 2 Diabetes

目的观察参芪复方加减治疗2型糖尿病大血管病变的证候疗效及对生活质量的影响。方法将120例2型糖尿病大血管病变患者随机分为治疗组和对照组各60例。两组患者均给予糖尿病基础治疗包括健康教育、饮食、运动、降糖、降压、降脂,治疗组在基础治疗的同时予参芪复方加减治疗,每日1剂,两组疗程均为8周。观察治疗前后两组患者中医证候积分、生活质量、空腹血浆葡萄糖(FPG)、2h血浆葡萄糖(2hPG)、糖化血清蛋白(GSP)变化情况,分析生活质量与FPG、2hPG、GSP的相关性。结果治疗组证候疗效总有效率为94.7%,对照组为76.8%,治疗组优于对照组(P<0.05)。两组患者治疗后中医证候积分、FPG、2hPG、GSP水平均明显降低(P<0.05或P<0.01),治疗组治疗后中医证候积分、FPG、2hPG、GSP水平均明显低于对照组(P<0.05或P<0.01)。治疗组治疗后生活质量各维度及总评分均较治疗前明显提高(P<0.01),并在躯体疼痛、总体健康、精力、社会功能、心理健康及总评分方面优于对照组(P<0.05或P<0.01)。生存质量总评分与血糖无显著相关性(P>0.05)。结论参芪复方加减治疗2型糖尿病大血管病变能明显提高证候疗效及患者的生活质量。

Objective To observe the efficacy of Modified Shenqi Compound Modified Renshen （Radix et Rhizoma Ginseng） and Huangqi （Radix Astragali） Compound on syndrome and quality of life （QOL） in patients with macrovascular disease （MVD） of type 2 diabetes. Methods Totally 120 cases of MVD of type 2 diabetes were randomized into treatment group and control group, with 60 in each. Both groups were given conventional treatment for diabetes including health education, diet control, excercise, as well as control of blood glucose, blood pressure and lipid. The treatment group was added with Modified Shenqi Compound one dose daily. The treatment lasted for 8 weeks. The changes of TCM pattern score, QOL, fasting plasma glucose （FPG）, 2-hour plasma glucose （2hPG） and glycosylated serum protein （GSP） were observed in both groups before and after treatment. The correlation of QOL and FPG, 2hPG and GSP was analyzed. Results The total effective rate of pattern score of the treatment group and control group was 94.7% and 76.8% respectively, with significant difference between groups （P0.05）. The level of TCM pattern score, FPG, 2hPG and GSP was significantly decreased in both groups after treatment （P0.05 or P0.01）, especially in the treatment group （P0.05 or P0.01）. The total score and each dimension of QOL in the treatment group was significantly increased after treatment （P0.01）. The total score, body pain, general health, energy, social function and mental health in the treatment group was superior to that in the control group （P0.05 or P0.01）. There was no significant correlation between QOL total score and plasma glucose （P0.05）. Conclusion Modified Shenqi Compound can obviously improve the pattern efficacy and QOL for MVD of type 2 diabetes.