第一过渡系金属手性双核催化剂和相应的非线性效应研究进展

Research and Progress in Chiral Binuclear Catalyst of First Row Transition Metal and Corresponding Nonlinear Effect

第一过渡系金属(3d金属)手性双核配合物的研究已渗透到不对称催化、生物酶模拟、功能超分子材料、医药等众多领域,是当前非常具有吸引力和应用前景的研究热点.相比传统的单核金属有机催化剂,第一过渡系金属手性双核配合物因催化活性中心的增加以及双核间的协同作用,在许多对映选择性反应中表现出优异的性能.综述了近10年来,多种第一过渡系金属(V,Ti,Mn,Fe,Co,Ni,Cu,Zn)手性双核催化剂在不对称反应中研究进展,如不对称加成、动力学拆分、选择性氧化、不对称聚合等反应.同时,对基于同-或异-手性双核配合物的非线性效应研究近况进行了简单的探讨.

The study on chiral binuclear complexes of first row transition metal has been expended to correlated fields such as asymmetric catalysis, biomimetic, functional supramolecular material and medicine, and reaches a research hot point of vast attraction and potential. Contrasting with other traditional organic-metal catalysts, the chiral binuclear complexes which com- bine several chiral centers and cooperated binuclear often play preferable catalysis behavior in enantioselective reaction. This review covers the recent progress in chiral binuclear complexes of V, Ti, Mn, Fe, Co, Ni, Cu, Zn applied in asymmetric reac- tions involving asymmetric addition, kinetic resolution, selective oxidation, asymmetric polymerization, as well as the mecha- nistic investigations. Some studies on the nonlinear effect along with the dimer catalysts are also discussed. The challenges and perspectives are given at the end of this article.