Lucidone和Methyl Lucidone的简洁合成

Concise Synthesis of Lucidone and Methyl Lucidone

报道了lucidone和methyl lucidone的简洁合成,其关键步骤为方酸二甲酯的还原/重排"一锅"反应和单甲氧基环丁烯二酮的达森/扩环反应.Lucidone的合成经过两步反应以46%的总收率实现.Methyl lucidone的合成经过三步反应以43%的总收率完成.

The concise synthesis of lucidone and methyl lucidone is reported. The key steps include the one-pot reduc- tion/rearrangement of dimethyl squarate and the Darzens/ring expansion of the monomethoxyl cyclobutenedione. The synthe- sis of lucidone was finished in two steps and 46% total yield. And the synthesis of methyl lucidone had been reached in three steps and 43% overall yield.