多肽PrP106-126对小脑颗粒神经元凋亡相关基因表达的影响

Effects of Peptides PrP106-126 on Cerebellar Granule Neuron Apoptosis-related Genes Expression

试验旨在研究多肽PrP106-126对小脑颗粒神经元凋亡相关基因表达的影响。本研究利用多肽PrP106-126作用于小脑颗粒神经细胞,对该多肽影响小脑颗粒神经细胞凋亡基因的表达进行了检测。结果表明:bax、caspase-3和myc基因在PrP106-126多肽作用后表达显著增加,而bcl-2基因表达明显下降,进一步验证了bax、caspase-3和myc基因具有诱导凋亡作用,而bcl-2基因则具有抑制凋亡作用。

The study focused on the effects of peptides PrP106-126 on cerebellar granule neuron apoptosis-related genes ex- pression. In this study, we detected expression changes of the cerebellar granule neuronal apoptosis gene affected by the pep- tide PrP106-126. The results showed that the expression of bax, caspase-3 and myc genes increased significantly after stimula- ted. On the contrary, the bcl-2 gene expression decreased significantly, which further confirmed that bax, caspase-3 and myc genes could induce cell apoptosis and bcl-2 gene could inhibit cell apoptosis.