猪繁殖与呼吸综合征病毒细胞受体研究进展

Research Progress on Cellular Receptors of Porcine Reproductive and Respiratory Syndrome Virus

猪繁殖与呼吸综合征病毒(porcine reproductive and respiratory syndrome virus,PRRSV)主要是通过与宿主细胞表面的特异性受体结合,利用细胞的内吞作用而感染易感细胞。作者对猪繁殖与呼吸综合征病毒相关受体的研究进行了综述,迄今已报道了5种独立的但功能相关的受体:硫酸乙酰肝素、唾液酸黏附素、波形蛋白、CD163和非肌肉肌动蛋白ⅡA。对受体的功能特性进行研究,将为PRRSV的感染机理和病毒性疾病的预防和治疗具有重要的意义。

Porcine reproductive and respiratory syndrome virus （PRRSV） enters the host ceils via a mechanism of receptor- mediated endocytosis. The entry mechanism is mediated by attachment to one or more cellular receptors and/or coreceptor on the cell surface and internalization. This article mainly describes several receptors for PRRSV. As far, it is reported five recep- tors of PRRSV which are independent and associated, heparin sulphate （HS）, sialoadhesin （Sn）, vimentin, CD163 and non- muscle myosin Ⅱ A. It plays a significant role for the mechanism of PRRSV infection or disease prevention and treatment by studying the function of cellular receptors of PRRSV.