蓝科肤宁对预防抗肿瘤药物致化学性静脉炎效果的基础研究

The basic research of Velvet-feeling in prevention of chemical phlebitis caused by anticancer drugs

目的观察蓝科肤宁湿敷后对氟尿嘧啶致兔耳静脉炎的防护作用。方法建立氟尿嘧啶致化疗性兔耳静脉炎模型，将24只实验兔用随机数字表法分为3组：A组采用蓝科肤宁湿敷进行干预，B组作为空白对照，C组采用喜疗妥外涂进行干预。干预前后均评估血管，观察血管外观变化及静脉炎发生情况，并于静脉滴注氟尿嘧啶24h后取局部静脉及周围组织进行病理切片、HE染色、光镜下分析并评价静脉及周围组织病理损伤程度。结果A、C2组静脉炎发生程度均较B组低，差异有统计学意义；A组和C组的静脉炎发生程度存在差异，尤其在血管壁炎细胞浸润和血管周围组织水肿程度这两方面，差异有统计学意义。结论早期应用蓝科肤宁湿敷或喜疗妥外涂对氟尿嘧啶所致化疗性静脉炎均起到较好的防护作用，并且蓝科肤宁湿敷的防护效果优于喜疗妥外涂。

Objective To observe the protective effect of Velvet-feeling on phlebitis in rabbit ears induced by Fluorouracil. Methods The models of Fluorouracil induced phlebitis in rabbit ears were es-tablished. 24 rabbits were randomized into three groups： group A used Velvet-feeling for wet dressing, group B was the blank control, group C was coated with Hirudoid. The vein was assessed before and after the intervention, and the changes in appearance of vein and the occurrence of phlebitis were observed. The samples of local vein and surrounding tissues were cut off 24 hours after intravenous injection of Fluo- rouracil and were made pathological sections, HE staining. The pathological damage degree of the vein and surrounding tissues were evaluated by light microscopy. Results The degree of phlebitis in group A and C were lower than group B, there was significant difference. There was significant difference between group A and C at the degree of phlebitis, especially in infiltration of inflammatory cells of vessel wall and perivas-cular edema. Conclusions Early application of the Velvet-feeling or Hirudoid coating were better in preven-tion of Fluorouracil induced phlebitis, and wet dressing of Velvet-feeling was better than Hirudoid coating.