血管紧张素转换酶在肺损伤中作用的研究进展

Advances in effects of angiotensin converting enzyme on lung injury

背景急性肺损伤（acute lung injury，ALI）／急性呼吸窘迫综合征（acute respiratory distress syndrome，ARDS）是一种炎性综合征，近年研究发现血管紧张素转换酶（angiotensin converting enzyme，ACE）在其发生发展过程中起着重要作用。目的人们对于。肾素血管紧张素系统renin angiotensin system，RAS），特别是ACE在肺损伤中的作用研究日趋深入，有必要了解其研究现状和未来趋势。内容重点就近几年来国内外对ACE在各种原因导致的肺损伤中作用的研究作一综述。趋向血管紧张素转换酶抑制剂（angiotensinconvertingenzymeinhibitors，ACEI）和血管紧张素Ⅱ（angiotensin11，ATlI）受体阻断剂在各种肺损伤中的应用已取得肯定成果，使人们对RAS和其在肺损伤中作用的认识不断加深。

Background Acute lung injury （ALI） or acute respiratory distress syndrome （ARDS） is a kind of inflammatory syndrome. Recent research showed that angiotensin converting enzyme （ACE） plays an important role in the development of ALI. Objective Study on renin angiotensin system （RAS）, especially the role of ACE in lung injury is growing, it is necessary to understand the current research and future trends. Content The focus of this review is to summarize the relevant studies about ACE in lung injury. Trend The application of angiotensin converting enzyme inhibitor （ACEI） and angiotensin II （AT lI ） receptor blockers in various lung injury has made positive achievements, which make people understand the role of RAS in lung injury deeply.