蛋白激酶Cα相互作用蛋白在瑞芬太尼痛觉过敏中的作用

Role of protein interacting with Cα kinase in remifentanil induced hyperalgesia

背景瑞芬太尼痛觉过敏是指应用瑞芬太尼所导致的机体对伤害性刺激的反应增强，其发生机制与N－甲基-D-天冬氨酸（N-methyl-D-asparticacid，NMDA）受体一蛋白激酶c（proteinkinaseC，PKC）通路介导的脊髓中枢敏化相关。蛋白激酶cα相互作用蛋白（protein interacting with Cα kinase，PICKl）是PKC。的靶蛋白之一，也是在PKCα和突触后膜受体蛋白间起重要作用的衔接蛋白。目的探讨PICKl在瑞芬太尼痛觉过敏发生及维持中的作用。内容对PICKl的结构、功能及其在瑞芬太尼痛觉过敏中的研究进行综述。趋向通过PICKl在瑞芬太尼痛觉过敏中的研究，为瑞芬太尼痛觉过敏的预防及治疗提供新的靶点。

Background Remifentanil therapy aiming at alleviating pain may render patients more sensitive to pain, which is defined as remifentanil induced hyperalgesia. N-methyl-D-aspartic acid （NMDA） receptor-protein kinase C （PKC） mediated spinal central sensitization is involved in the mechanisms of remifentanil induced hyperalgesia. Protein interacting with Cα kinase （PICK1） is one of the target proteins of protein kinase Cα. PICK1 is an important adapter protein between PKCα and postsynaptic receptors. PICK1 contains a PDZ domain and a BAR domain. PICKI plays important roles in synaptic plasticity, neural conduction, peripheral nerve sensation, cell growth and cytoadherence. Objective This review focus on the role of PICKI in remifentanil induced hyperalgesia. Content This review provides a comprehensive summary of structure and function of PICK1 as well as its progressions in remifentanil induced hyperalgesia. Trend PICK1 may provide a new way for the treatment of remifentanil induced hvperalgesia.