肥大细胞与肿瘤血管生成

Mast cells and tumor angiogenesis

肥大细胞（MC）是起源于骨髓，定居于组织的免疫细胞。肿瘤可以通过干细胞因子（SCF）及其在肥大细胞上的受体c-kit来介导对MC的募集。MC在肿瘤部位的数量和分布与肿瘤的生长、血管新生密切相关。MC可以通过释放血管生成因子介导血管新生，促进肿瘤的进展。

Mast cells （MCs） are bone marrow-derived and tissue-homing immune cells which have important functions. Recruitment and activation in tumors are demonstrated to be mainly mediated by tumor- derived stem cell factor （SCF） and its receptor c-kit on MCs. The numbers and distributions of MCs in tumors are closely related to the growth of tumors and angiogenesis. MCs can mediate angiogenesis by releasing a series of angiogenesis factors, so as to promote the progress of tumors.