G蛋白偶联受体C型家族5A与肺癌

GPRCSA and lung cancer

G蛋白偶联受体C型家族5A（GPRC5A）是由维甲酸诱导的基因，主要分布在肺组织，在肺癌中的表达远低于癌旁正常组织，小鼠该基因敲除导致肺癌的发生，因此被证明是肺癌的抑癌基因，有望成为肺癌诊断新的标志物及治疗的新靶点。

The G protein-coupled receptor family C, member 5, group A （GPRC5A） gene is known as retinoie acid-induced gene, which is mainly distributed in lung tissue. The expression of GPRC5A in lung cancer is significantly decreased compared with normal lung. GPRC5A leads to lung cancer through knockout mice, which is proven to be a suppressor gene of lung cancer. GPRC5A may be a novel biomarker for the diagnosis of lung cancer and a new target for the treatment of lung cancer.