摘要
Cardiovascular disease （CVD） is a leading cause of morbidity and mortality. The risk factors for CVD include environmental and genetic components. Human mutations in genes involved in most aspects of cardiovascular function have been identified, many of which are involved in transcriptional regulation. The Mediator complex serves as a pivotal transcriptional reg- ulator that functions to integrate diverse cellular signals by multiple mechanisms including recruit- ing RNA polymerase II, chromatin modifying proteins and non-coding RNAs to promoters in a context dependent manner. This review discusses components of the Mediator complex and the contribution of the Mediator complex to normal and pathological cardiac development and func- tion. Enhanced understanding of the role of this core transcriptional regulatory complex in the heart will help us gain further insights into CVD.
Cardiovascular disease （CVD） is a leading cause of morbidity and mortality. The risk factors for CVD include environmental and genetic components. Human mutations in genes involved in most aspects of cardiovascular function have been identified, many of which are involved in transcriptional regulation. The Mediator complex serves as a pivotal transcriptional reg- ulator that functions to integrate diverse cellular signals by multiple mechanisms including recruit- ing RNA polymerase II, chromatin modifying proteins and non-coding RNAs to promoters in a context dependent manner. This review discusses components of the Mediator complex and the contribution of the Mediator complex to normal and pathological cardiac development and func- tion. Enhanced understanding of the role of this core transcriptional regulatory complex in the heart will help us gain further insights into CVD.
基金
supported by the American Heart Association(Grant No. 13SDG14660064)
