白僵蚕化学成分的基础研究

Study on Chemical Constituents of Bombyx Batryticatus

目的：对白僵蚕的化学成分进行分离鉴定。方法：采用溶剂提取、萃取、反复硅胶柱色谱（ODS、制备液相色谱法）等方法进行分离纯化，根据化合物的理化性质和谱学数据鉴定其结构。结果：从白僵蚕分离得到4个化合物，分别鉴定为3β,5α-二羟基-（22E,24R）-麦角甾-7,22-二烯-6-酮（1）、（22E,24S）-5α,8α-环二氧-24-甲基-胆甾-6,9（11）,22-三烯-3β-醇（2）、高精氨酸（3）、β-谷甾醇（4）。结论：化合物1～3为首次从该药材中分离得到。

Objective： To investigate the chemical constitutents of Bombyx batryticatus. Methods： The compounds were isolated by means of solvent extraction, abstraction, chromatography on silica gel, ODS, and preparative RP-HPLC. The structures were identified by spectral analysis and physicochemical evidence. Results： Four compounds were isolated from the Bombyx Batryticatus and identified as 3fl, 5 a-dihydroxy- （ 22E, 24R） -ergosta-7,22-diene-6-one （1）, （22E,24S）-5α,8α-epidioxy-24-methylcholesta-6,9（ 11 ） ,22-trien-3β-ol （2） ,homoarginine （3）, and β-sitosterol （4）. Conclusion： Compounds 1 - 3 were isolated from B. Batryticatus for the first time.