急性缺血性脑血管病血清内皮素、血糖、肌酐及尿素氮水平的临床研究

Acute ischemic cerebrovascular disease,endothelin,blood glucose,serum creatinine and urea nitrogen levels in clinical research

目的探讨急性缺血性脑血管病(ICVD)发病及进展程度与血清ET、BG、Cr及UN水平的关系,以期为ICVD发病机制和临床诊治提供理论依据。方法选取本院2011年-2012年间收治的急性ICVD患者79例(研究组),取空腹静脉血,测定血清ET、BG、Cr及UN水平;并与同期入院体检的健康志愿者61例(对照组)做对比分析,确定敏感指标。按神经功能缺损评分将79例急性ICVD患者分为轻度缺损21例(TCⅠ组),中度缺损33例(MCⅠ组),及重度缺损25例(SCⅠ组);比较各敏感指标的组间差异。结果敏感指标的确定:研究组患者ET及BG两项指标的水平显著高于对照组(P<0.05);Cr稍高于对照组,UN稍低于对照组,但差异均无统计学意义(P>0.05);以ET、BG为急性ICVD的敏感指标。敏感指标的比较:MCⅠ组患者ET及BG水平显著高于TCⅠ组(P<0.05);SCⅠ组患者ET及BG水平显著高于MCⅠ组(P<0.05);随着神经功能缺损的加重,其ET及BG水平均呈显著上升趋势。结论 ET与BG两项指标与急性ICVD的发病和进展密切相关,可作为急性ICVD的敏感因子进行实时监测;同时,也可从抗ET与降BG入手,摸索急性ICVD的治疗策略。

Objective To acute ischemic cerebrovascular disease （ICVD） onset and progression and serum levels of ET,BG,the relationship between Cr and the UN level,in order to provide theoretical basis for ICVD pathogenesis and clinical treatment. Methods From 2011 to 2012,79 cases with acute ICVD patients were treated （research group） ,fasting venous blood,serum ET,BG,Cr and UN level; And admission exami-nation in the same period 61 cases of healthy volunteers （control group） compare analysis,determine the sensi-tive index. According to the neural function defect scale will be 79 cases of acute ICVD patients were divided into mild defect 21 cases （TCI） ,33 cases moderate defect （MCI） ,25 cases （SCI） and severe defect; Compa-ring the sensitive index of the differences between two groups. Results Sensitive indicators to determine： the team both in patients with ET and BG level was significantly higher than control group （P〈0.05） ; Cr was slightly higher than the control group,the UN was slightly lower than the control group,but there was no signifi-cant difference （P〈0.05） ; With ET,BG for sensitive indicator of acute ICVD. Sensitive index of compari-son： ET and BG levels in patients with MCI group was significantly higher than in TCI group （P〈0.05） ; SCI group had a significantly higher in patients with ET and BG level MCI group （P〈0.05） ; As neural function defect was aggravating,the ET and BG levels were significantly rising trend. Conclusion Both ET and BG is closely related to the onset and progress of acute ICVD,real-time monitoring can be used as a sensitive factor of acute ICVD; At the same time,also can from resistance to ET and BG,and grope for acute ICVD treatment strategies.