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FLT3-ITD基因突变与急性白血病的临床研究 被引量：1

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摘要 目的探讨人Fms样酪氨酸激酶3内部串联重复基因突变(FLT3-ITD)检测对急性白血病的诊断价值。方法通过聚合酶链反应-变性高效液相色谱法,检测本院35例急性白血病患者(观察组)和35例健康体检者(对照组)骨髓FLT3-ITD基因突变情况。结果与对照组相比,观察组阳性率明显升高,P<0.05;与阴性患者相比,观察组阳性患者外周血白细胞计数、白细胞比例均明显升高,完全缓解率显著降低,P<0.05。结论 FLT3-ITD基因突变可作为急性白血病诊断和治疗的参考指标。
作者 徐玉秀 张勇刚 许春玲
机构地区 河南省驻马店市中心医院血液科
出处 《中国实用医药》 2013年第18期118-119,共2页 China Practical Medicine
关键词 FLT3 ITD 基因突变 急性白血病
分类号 R733.71 [医药卫生—肿瘤]
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共引文献43

同被引文献14

  • 1王莉红,周春林,张新伟,陈森,王敏,王建祥.FLT3基因内部串联重复突变与急性白血病的关系及临床意义[J].中华血液学杂志,2004,25(7):393-396. 被引量：35
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中国实用医药
2013年 第18期

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