摘要
目的:探讨缺血性中风病中医证候要素动态变化与NIHSS评分变化之间的关系。方法:以379例缺血性中风病临床数据为基础,在5个不同时点(0d、3d、14d、28d、3m)采集《中风病辨证诊断标准》中风、火、痰、瘀、气虚、阴虚阳亢6个证候要素的评分和《美国国立卫生院卒中量表》(NIHSS)评分,运用贝叶斯网络分析其相关性。结果:0~3d时,NIHSS评分改善,证候要素痰、瘀、阴虚阳亢和气虚的改善概率分别为0.809、0.896、0.934、0.961;3~14d时,火热、瘀、痰、阴虚阳亢和气虚的改善概率分别为0.546、0.843、0.895、0.962、0.944;14~28d时,火热、痰、阴虚阳亢和气虚的改善概率分别为0.53、0.815、0.966、0.987;28d至3m时,风、火热、瘀、痰、阴虚阳亢和气虚的改善概率分别为0.507、0.667、0.854、0.505、0.905、0.914,与NIHSS呈现出明显的正向关系。结论:缺血性中风病的NIHSS评分变化在不同时点均有多个证候要素评分与之相关,其相关程度随时间动态演变。
Objective:To investigate the correlation between TCM syndrome dynamic changes and NIHSS scores of ischemia stroke.Methods:The patients with ischemia stroke(n = 379) were selected and their scores of six syndrome factors(wind,fire,phlegm,stasis,qi-deficiency and hyperactivity of yang due to yin-deficiency) according to the Diagnostic Standard of Syndrome Differentiation of Stroke and the National Institutes of Health Stroke Scale(NIHSS) at 5 different time points(0d,3d,14d,28d,3m) were recorded respectively.The correlation between syndrome factors and NIHSS scores at different time points were studied by using the method of Bayesian network.Results:NIHSS were improved during 0d-3d,and the improvement rate of phlegm,stasis,hyperactivity of yang due to yin-deficiency and qi-deficiency were respectively 0.809,0.896,0.934,0.961;during 3d-14d,the improvement rate of fire,stasis,phlegm,hyperactivity of yang due to yin-deficiency and qi-deficiency were 0.546,0.843,0.895,0.962,0.944;during 14d-28d,the improvement rate of fire,phlegm,hyperactivity of yang due to yin-deficiency and qi-deficiency were 0.53,0.815,0.966,0.987;during 28d-3m,the improvement rate of wind,fire,stasis,phlegm,hyperactivity of yang due to yin-deficiency and qi-deficiency were 0.507,0.667,0.854,0.505,0.905,0.914.Conclusion:There is a correlation between TCM syndrome factors manifestations and NIHSS scores in ischemia stroke at different time points,and the correlation degree changes dynamically over time.
出处
《世界中医药》
CAS
2013年第6期613-617,共5页
World Chinese Medicine
基金
国家自然科学基金课题(编号:30873460)
构建表征证候动态变化纵向结局评价指标的示范研究
中医药行业科研专项课题(编号:201107006)
中医慢病临床科研体系及其成果转化应用模式研究