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胃癌术前辅助治疗原发灶病理完全缓解16例病例报告 被引量:4

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摘要 目的 :分析胃癌术前辅助治疗后原发病灶病理学完全缓解(pathological complete response,pCR)患者的临床特征并讨论原发灶pCR病例的后续治疗方法。方法:筛选江苏省中医院2006~2012年接受术前辅助治疗的胃癌病例中原发病灶pCR的16例临床资料,分析其临床特征,结合目前已有的临床试验结果讨论其个体化治疗策略。结果:16例治疗前原发灶肿瘤临床分期均为T2以上,采用表阿霉素+顺铂+氟尿嘧啶(ECF方案)。2例术后病理提示有淋巴结转移,8例术后未行辅助治疗。所有患者至今均无病生存,提示预后好。结论:术前辅助治疗能改善胃癌总体生存率,但现有胃癌术前辅助治疗方案的病理缓解率较低,有待改良,pCR病例的临床预后良好,其后续治疗方法有待进一步研究。
出处 《南京医科大学学报(自然科学版)》 CAS CSCD 北大核心 2013年第7期921-923,共3页 Journal of Nanjing Medical University(Natural Sciences)
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  • 1Frei E 3rd.Clinical cancer research:an embattled species [J].Cancer,1982;50(10):1979
  • 2Wilke H,Preusser P,Fink U,et al.Preoperative chemotherapy in locally advanced and nonresectable gastric cancer:a phase II study with etoposide,doxorubicin,and cisplatin [J].J Clin Oncol,1989;7(9):1318
  • 3Kollmannsberger C,Quietzsch D,Haag C,et al.A phase Ⅱ study of paclitaxel,weekly,24-hour continous infusion 5-fluorouracil,folinic acid and cisplatin in patients with advanced gastric cancer [J].Br J Cancer,2000;83(4):458
  • 4Lowy AM,Mansfield PF,Leach SD,et al.Response to neoadjuvant chemotherapy best predicts survival after curative resection of gastric cancer [J].Ann Surg,1999;229(3):303
  • 5Plukker JT,Mulder NH,Sleijfer DT,et al.Chemotherapy and surgery for locally advanced cancer of the cardia and fundus:phase Ⅱ study with methotrexate and 5-fluorouracil [J].Br J Surg,1991;78(8):955
  • 6Kiyabu M,Leichman L,Chandrasoma P.Effects of preoperative chemotherapy on gastric adenocarcinomas.A morphologic study of 25 cases [J].Cancer,1992;70(9):2239
  • 7Shchepotin IB,Chorny V,Hanfelt J,et al.Palliative superselective intra-arterial chemotherapy for advanced nonresectable gastric cancer [J].J Gastrointest Surg,1999;3(4):426
  • 8Yonemura Y,Kawamura T,Bando E,et al.Treatment results of peritoneal dissemination from gastric cancer by neoadjuvant intraperitoneal-systemic chemotherapy [J].Gan To Kagaku Ryoho,2004;31(11):1723
  • 9Yano M,Yasuda T,Fujiwara Y,et al.Preoperative intraperitoneal chemotherapy for patients with serosa-infiltrating gastric cancer [J].J Surg Oncol,2004;88(1):39
  • 10Macdonald JS.Clinical overview:adjuvant therapy of gastrointestinal cancer [J].Cancer Chemother Pharmacol,2004;54 Suppl 1:S4

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  • 1Roberto Biffi,Nicola Fazio,Fabrizio Luca,Antonio Chiappa,Bruno Andreoni,Maria Giulia Zampino,Arnaud Roth,Jan Christian Schuller,Giancarla Fiori,Franco Orsi,Guido Bonomo,Cristiano Crosta,Olivier Huber.Surgical outcome after docetaxel-based neoadjuvant chemotherapy in locally-advanced gastric cancer[J].World Journal of Gastroenterology,2010,16(7):868-874. 被引量:43
  • 2徐少杰,黎庆荣,龚伟,纪建松.胃癌淋巴结大小与转移的关系[J].肿瘤学杂志,2005,11(6):447-448. 被引量:13
  • 3刘福坤,姚学权.胃癌的新辅助化疗[J].中国普外基础与临床杂志,2006,13(1):17-20. 被引量:25
  • 4Cunningham D,Allum WH,Stenning SP,菅鑫妍.手术期间化学疗法与单独手术治疗可切除的胃食管癌疗效比较[J].中国处方药,2006,5(8):59-60. 被引量:434
  • 5Siegel R,Naishadham D,Jemal A.Cancer Statistics[J].CA Cancer J Clin,2013,63:11-30.
  • 6Jung KW,Won YJ,Kong HJ,et al.Cancer statistics in Korea:incidence,mortality,survival and prevalence in2010[J].Cancer Res Treat,2013,45:1-14.
  • 7Guggenheim DE,Shah MA.Gastric cancer epidemiology and risk factors[J].Journal of Surgical Oncology,2013,107:230-236.
  • 8Yoshikawa T,Tanabe K,Nishikawa K,et al.Induction of a pathological complete response by four courses of neoadjuvant chemotherapy for gastric cancer:early results of the randomized phaseⅡCOMPASS Trial[J].Ann Surg Oncol,2014,21(1):213-219.
  • 9Therasse P,Arbuck SG,Eisenhuner EA,et al.New guidelines to evaluate the response to treatment in solid tumors[J].J Natl Cancer Inst,2000,92(3):215-216.
  • 10Ott K,Lordick F,Herrmann K,et al.The new credo:induction chemotherapy in locally advanced gastric cancer:consequences for surgical strategies[J].Gastric Cancer,2008,11(1):1-9.

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