牙源性透明细胞癌的临床病理分析

Clinical pathological analysis of clear cell odontogenic carcinoma

目的 探讨牙源性透明细胞癌的临床、病理学特点及生物学行为。方法 对 8例牙源性透明细胞癌的临床资料进行分析 ,进行术后标本、石蜡切片、HE染色及特染光镜观察 ,1例行电镜观察。结果 牙源性透明细胞癌的发生女性明显多于男性 ,好发于下颌骨 ;区域淋巴结转移率为37 5 % ,33 3%术后复发 ;肿瘤由透明细胞和基底样细胞形成团块和条索 ,瘤组织紧贴血管 ,呈浸润性生长 ;电镜下可见透明细胞的细胞器少 ,线粒体肿胀变性。结论 牙源性透明细胞癌的生物学行为是一种中度恶性的肿瘤。

Objective To investigate clinical pathological characteristics and biologic behavior of clear cell odontogenic carcinoma Methods Analysis of clinical data, microscopic and electromicroscopic observation of 8 cases of clear cell odontogenic carcinoma Results The tumor occurred mainly in female and involved right mandible 37 5% had regional lymph node metastases at the time of operation Recurrence rate was 33 3% The tumor had no capsule and consisted of clear cell and basaloid cells which arranged in nests and strands Tumor cells often grew close to the blood vessels and caused bone resorption There were less cell organelle and swelling of mitochondria Conclusion This tumor belongs to middle grade malignant tumor and should be called clear cell odontogenic carcinoma