深圳市宝安区2006-2010年围产儿唇腭裂监测结果分析

Analyzing Results of Monitoring Perinatal Cleft Lip and Palate in Bao'an District of Shenzhen Between 2006 and 2010

目的对深圳市宝安区5年围产儿出生缺陷监测结果进行分析,以了解深圳市宝安区唇腭裂发生的流行情况。方法应用SPSS 13.0软件对宝安区2006—2010年出生缺陷监测资料进行统计分析。结果 5年间宝安区国产儿中共有374例唇腭裂患儿,其年均发生率为1.40‰;各类唇腭裂的年均发生率从高到低依次为唇裂合并腭裂(0.72‰)、单纯唇裂(0.48‰)和单纯腭裂(0.20‰);不同户籍类型的唇腭裂发生率从高到低依次为流动人口(1.51‰)、暂住人口(1.13‰)和户籍人口(0.69‰);男性单纯唇裂、唇裂合并腭裂的发生率均高于女性,而女性单纯腭裂的发生率则高于男性;在所有唇腭裂患儿中,有77例(20.59%)伴发其他类型的先天畸形,主要为肢体畸形、先天性心脏病和颜面部畸形。结论唇腭裂在宝安区出生缺陷构成比中位居前列,有效降低唇腭裂的发生率是宝安区的一项重要任务;加大对流动人口的健康教育力度以及进一步阐明不同类型的唇腭裂发病机理,有利于控制唇腭裂的发生。

OBJECTIVE To analyze the monitoring results of perinatal birth defects in Bao＇ an District of Shenzhen over five year period, for the sake of getting insight into the prevalence of cleft lip and palate. METHODS SPSS 13.0 software was used for statistical analysis of perinatal birth defects in Bao＇an District from 2006 to 2010. RESULTS There were 374 cases of perinatal cleft lip and/or palate in Bao＇an District of Shenzhen over five year period, with an incidence of 1.dO~. The incidences of different types of cleft lip and/or palate, from the highest to the lowest, were as followed： cleft lip and palate（0.72%o）, isolated cleft lip（0.48%~）, isolated cleft palate （0.20%0）. The incidences of cleft lip and palate in different types of household registry, from the highest to the lowest, were as followed： floating population（1.51%o）, temporary population（1.13%o）, household population（0.69%o）. The incidences of cleft lip and palate, isolated cleft lip in male were higher than those in female, while the incidence of isolated cleft palate in female was higher than that in male. A total of 77（20.59%） of all cases had extra malformation in addition to cleft lip and palate, which mainly included limbs malformation, congenital heart disease and facial malformation. CONCLUSIONS Cleft lip and palate was in the front rank in the constituent ratio of births defects in Bao＇ an District. Effectively reduced the incidence of cleft lip and/or palate was an important task for Bao＇an District. Health education should be strengthened in the floating population, as well as further progress in clarifying the pathogenesis of different types of cleft lip and palate to control the incidence of cleft lip and palate.