应用光学相干断层成像术测量正常人视网膜神经纤维层厚度

Optical coherence tomography applied for measurement of nerve fiber layer thickness in normal eyes

目的 评价光学相干断层成像术（ｏｐｔｉｃａｌ ｃｏｈｅｒｅｎｃｅ ｔｏｍｏｇｒｄｐｈｙ，ＯＣＴ）在正常人视网膜神经纤维层（ｒｅｔｉｎａｌ ｎｅｒｖｅ ｆｉｂｅｒ ｌａｙｅｒ，ＲＮＦＬ）厚度测量中的星夜价值及其测量重复性，探讨正常人各年龄组之间ＲＮＦＬ厚度是否存在差异。方法 用ＯＣＴ对１５２例（１５２只眼）正常人进行以视乳头中点为中尽，直径为３．４６ｍｍ圆周的ＲＮＦＬ厚度测量，将检查者按１０岁为一个

Objective To evaluate the efficiency of optical coherence tomography (OCT) on quantifying retinal nerve fiber layer (RNFL) thickness and its reproducibiliity and investigate the difference of RNFL thickness between different groups Methods According to their age, 152 eyes of 152 normal subjects were classified into six groups (such as 10~ year, 20~ year group, etc ), and investigated by OCT to measure the RNFL thickness Each subject had circular scans around the optic nerve with a circle size of 3 46 mm The RNFL thickness in different groups was analyzed Intraclass correlation coefficient (ICC) in fifty eyes of 37 subjects was calculated Results The mean RNFL thickness of 152 eyes was (90 09±10 81) μm, (140 27±10 60) μm, (85 03±14 01) μm, (140 27±9 70) μm and (114 11±6 08) μm (temporal, superior, nasal, inferior and the mean of the whole layer, respectively) Least significant difference (LSD) t test was applied for multiple thickness comparisons of the mean and different uadrants among different groups The results showed there were significant differences between the 60～ year group and others except the 50～ year group in temporal, superior, inferior quadrants and mean RNFL thickness ( P =0 000-0 019), and between each of 10～ to 40～ year groups and each of 50～ to 60～ year groups in the mean RFNL thickness ( P =0 000-0 026) ICCs of RNFL thickness measured by OCT were 0 78, 0 66, 0 64, 0 52 and 0 74 (temporal, superior, nasal, inferior and mean, respectively) Conclusions Normal RNFL thickness can be measured accurately by OCT There are some differences of RNFL thickness between different groups in normal persons