髓系细胞触发受体-1与血清淀粉样蛋白A在慢性阻塞性肺疾病急性加重中的临床价值研究

The clinical investigation of triggering receptor expressed on myeloid cell-1 and serum amyioid A in acute exacerbation of chronic obstructive pulmonary disease

慢性阻塞性肺疾病（chronic obstructive pulmonary disease,COPD）在全球范围内患病率极高,急性加重是其就诊、住院治疗及医疗开支的主要原因.目前的研究对细菌感染在急性加重患者中的作用意见不一,如能为抗菌治疗在慢性阻塞性肺疾病急性加重（AECOPD）提供早期、快速的客观依据将极有价值.髓系细胞触发受体1及血清淀粉样蛋白A是新近发现的标志物,两者在感染与非感染性炎症、细菌感染与非细菌感染性炎症中表达的不同,将为AECOPD疾病严重程度的评估、细菌感染的鉴别提供重要依据.

Due to high prevalence rate of chronic obstructive pulmonary disease （COPD）worldwide,acute exacerbation has been the major cause for out-patient clinics,hospitalization and increasing medical costs.The role that bacterial infection plays in acute exacerbation remains currently controversial,thus premature and prompt objective proofs for antimicrobial therapy may be of remarkable significance.Recently,triggering receptor expressed on myeloid cell-1 and serum amyloid A were revealed as biomarkers in acute exacerbation of COPD,and were of significance in assessing disease severity and offering proofs for bacterial infection based on their distinction in biological features in terms of infectious or non-infectious inflammation,bacterial infection and non-bacterial infectious inflammation.