针刺对大鼠实验性神经根压迫模型超微结构的影响

Effects of Acupuncture on Lumbar Nerve Root Compression——An Ultramicrostructure Study of the Rat Nerve Root

为探索针刺治疗腰神经根压迫症的作用途径 ,观察针刺对大鼠压迫神经根超微结构的影响 ,特选择实验动物SD雄性大鼠 2 5只 ,随机分为正常组、造模 1 5天组、造模后针刺治疗 1 5天组、造模 30天组及造模后针刺治疗 30天组。通过手术 ,将特制的硅胶片置于右侧L5 神经根出硬膜囊的交界处 ,观察针刺 1 5天、30天后对被压迫神经根超微结构的影响。结果表明 ,针刺治疗 1 5天组较造模 1 5天组脱髓鞘变减轻 ,雪旺氏细胞结构基本正常 ,针刺治疗 30天组能进一步改善髓鞘板层结构 ,并缓解神经根内水肿。提示针刺可改善模鼠压迫神经根超微结构 ,从而为探索针刺治疗神经根压迫症的原理提供了实验依据。

To explore the mechanism of acupuncture treatment for nerve root compression syndrome,25 SD(Sprague Dawley)rats were chosen.The rats were divided into five groups:the normal group,fifteenth day model group,fifteenth day acupuncture group,thirtieth day model group,thirtieth day acupuncture group.By operation,a piece of slastic of proper size and weight was gently put on the site where L 5 nerve root origins from the dural sheath.Effects of acupuncture on nerve root ultramicrostructure were studied.Compared with the fifteenth day model group,less nerve fibers whose schwann cells were proximately normal partly demyelinated in the fifteenth day acupuncture group,the myelin sheaths were more recovered and the intraradicular edema was relieved in the thirtieth day acupuncture group.The above results suggest that acupuncture can ameliorate the ultramicrostructure of the nerve root which is compressed,and provide evidence for acupuncture treatment on lumbar nerve root compression syndrome.