益肾化湿颗粒配合洛丁新治疗慢性肾小球肾炎临床观察

Clinical Observation of Yishen Huashi Granula Plus Lotensin in Treatment of Chronic Glomerulonephritis

目的:观察益肾化湿颗粒配合洛丁新治疗慢性肾小球肾炎的临床效果。方法:将68例慢性肾小球肾炎患者随机分为治疗组36例与对照组32例。2组患者均给予洛丁新(盐酸贝那普利片)口服,治疗组在此基础上加用益肾化湿颗粒口服,比较2组患者治疗前后24h尿蛋白定量变化及临床疗效。结果:总有效率治疗组为91.7%,对照组为62.5%,2组间比较,差异有显著性意义(P<0.05)。治疗组在减少24h尿蛋白定量方面优于对照组,2组比较,差异有显著性意义(P<0.05)。2组治疗前后血常规、血糖、血脂、肝肾功能无明显变化,治疗组未发现明显的不良反应。结论:益肾化湿颗粒配合洛丁新治疗慢性肾小球肾炎比单用洛丁新效果好,具有临床应用价值。

Objective: To observe the effects of Yishen Huashi Granula plus Lotensin in the treatment of chronic glomerulonephritis.Methods: Sixty-eight chronic glomerulonephritis patients were randomly divided into treatment group(n=36) and control group(n=32).Both groups were treated with Lotensin(benazepril hydrochloride tablets) orally,and the treatment group was given Yishen Huashi Granula,additionally.Before and after treatment,24-h urinary protein quantitation was compared,and the therapeutic effect was evaluated after treatment.Results:The total effective rate was 91.7% in the treatment group and was 62.5% in the control group,the difference being significant(P<0.05).Treatment group had better effect on decreasing 24-h urinary protein content than the control group(P<0.05).The indexes of routine blood examination,blood glucose,blood lipid,and hepatic and renal function remained unchanged in both groups before and after treatment.No obvious adverse reaction was shown in the treatment group.Conclusion:Yishen Huashi Granula plus Lotensin exerts better effect in the treatment of chronic glomerulonephritis than Lotensin alone.