摘要
积雪草酸及其衍生物是传统药用植物积雪草中含量较高并主要发挥活性的五环三萜类化合物,具有治疗皮肤损伤、抗癌、抗抑郁等多种药理活性,但口服生物利用度差。本研究通过查阅国内外相关文献,系统分析积雪草有效成分的吸收、分布、代谢和排泄(ADME)等药动学特点,探讨其口服生物利用度低的原因,并提出改善方法。
Asiatic acid and its derivatives are the most common triterpenoids in traditional popular medicinal herb Centella asiatica,and have been reported to possess various pharmacological activities such as anti-inflammatory,anticancer and antidepressant.However,their oral bioavailability is low.This article reviews recent advances in pharmacokinetics from the absorption,distribution,metabolism and excretion（ADME）,to figure out the possible causes for their low oral bioavailability,and further to investigate the strategy for bioavailability improvement.
出处
《中国现代应用药学》
CAS
CSCD
2013年第7期805-808,共4页
Chinese Journal of Modern Applied Pharmacy
基金
浙江省科技计划项目(2011F10048)
浙江省新世纪151人才工程(第二层次)
浙江省卫生高层次创新人才培养工程(2008)
浙江省医学重点学科群建设项目(XKQ-010-001)
关键词
积雪草有效成分
药动学
ADME
生物利用度
bioactive constituents of Centella asiatica
pharmacokinetics
ADME
bioavailability
