社区获得性肺炎病情严重度与降钙素原、C反应蛋白相关性的研究

Correlation analysis investigation between the severity of community acquired pneumonia and procalcitonin,C-reactive

目的探讨社区获得性肺炎(CAP)患者病情严重度与降钙素原(PCT)、C-反应蛋白(CPR)相关性。方法前瞻性收集2011年10月至2013年2月期间北京友谊医院感染内科、综合科、急诊病房住院的社区获得性肺炎且无肺部基础疾病患者共78例。在入院24小时、入院7天分别进行静脉血CRP和PCT水平检测,应用肺炎严重度指数(PSI)评分进行肺炎病情严重度评估。结果本组CAP患者中,入院第24小时和第7天PSI评分分别为(72.21±27.47)分和(64.58±36.4)分,CRP水平均在正常范围。入院24小时和第7天PCT值[(2.44±0.11)ng/ml和(1.83±0.90)ng/ml]均高于正常范围[(1.56±0.88)ng/ml]。入院24小时和第7天PCT与肺炎严重度指数(PSI)的相关系数r=0.539(P<0.01)和r=0.427(P<0.05),二者呈显著相关;CRP与PSI无相关性。结论 PCT水平与CAP患者的病情严重度存在相关性,CRP与病情严重程度无关。PCT对评估CAP患者的病情严重程度有一定价值。

Objective To analyze the correlation between the severity of community-acquired pneumonia（CAP） and procalcitonin（PCT）,C-reactive protein（CPR）.Methods Data were collected prospectively from October 2011 to February 2013.Patients who were diagnosed as CAP with and without lung disease from department of infectious diseases,emergency,comprehensive department in Beijing Friendship Hospital.A total of 78 cases were included into this study.The CRP and PCT levels of these patients were tested and pneumonia severity index（PSI） were calculated in 24 hours and 7th day of admission respectively.Results In this group of patients with CAP,PSI in admission 24 hours and 7th day were（72.21 ± 27.47） and（64.58 ± 36.4）,CRP levels were in the normal range.PCT were[（2.44 ± 0.11） ng / ml and（1.83 ± 0.90） ng / ml] in 24 hours and the 7th day of admission respectively,which were higher than the normal range [（1.56 ± 0.88） ng / ml].PCT in 24 hours and 7th day of admission were significantly correlated with PSI.The correlation coefficient were r = 0.539（P 0.01） and r = 0.427（P 0.05）.CRP had no correlation with the PSI.Conclusion PCT correlated with severity of the patients with CAP.CRP has nothing to do with the severity of CAP.It was valuable for assessing the severity of patients with CAP with PCT.