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白介素4受体与支气管哮喘 被引量:4

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摘要 支气管哮喘(哮喘)是由多种细胞特别是T细胞、肥大细胞和嗜酸粒细胞介导的慢性气道炎症,以气道高反应性和可逆性气道阻塞为特征。白介素 4受体(IL-4R)的α亚基作为 IL-4和 IL-13的受体,参与了哮喘的病理生理过程。本文就IL-4R的生物学功能及其与哮喘关系的研究进展作一综述。
作者 徐勤枝
出处 《国外医学(呼吸系统分册)》 2000年第3期121-123,共3页 Section of Respiratory System Foreign Medical Sciences
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参考文献10

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同被引文献35

  • 1Borish LC, Nelson HS, Corren J, et al. Efficacy of soluble IL-4 receptor for the treatment of adults with asthma. J Allergy. Clin Immunol, 2001;107:963 - 970.
  • 2Borish LC, Nelson AS, Lanz M J, et al. Interleukin-4 receptor in moderate atopic asthma. A phase Ⅰ/Ⅱ randomized, placebo-controlled trial. Am J Respir Grit Care Med, 1999; 160:1816 - 1823.
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  • 4Tournoy KG, Kips JC, Pauwels RA. Is Th 1 the solution for Th2 in asthma?Clin Exp Allergy, 2002 ; 32 : 17 - 29.
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  • 7Mosley B, Beckmann MP, March C J, et al. The murine interleukin-4 receptor: molecular cloning and characterization of secreted and membrane bound forms .Cell , 989;59:335 - 348.
  • 8Borish LC,Nelson HS,Corren J,et al.Efficacy of soluble IL-4 receptor for the treatment of adults with asthma.J Allergy Clin Immunol,2001; 107:963-970
  • 9Henderson WR Jr,Lewis DB,Albert RK,et al.The importance of leukotrienes in airway inflammation in a mouse model of asthma.J Exp Med,1996; 184:1483-1494
  • 10Tournoy KG,Kips JC,Pauwels RA.Is Th1 the solution for Th2 in asthma.?Clin Exp Allergy,2002; 32:17-29

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