中西医结合治疗老年晚期肺癌的临床研究

Clinical study on treating advanced lung cancer in elderly with integrated traditional Chinese and western medicine

比较老年晚期肺癌患者在化疗基础上加用中药治疗与单纯化疗、单纯中药治疗的临床效果。方法:将104例老年晚期肺癌患者随机分为化疗组(22例)、中药组(34例)、中西医结合组(48例)。化疗组采用MVP方案,即丝裂霉素4～8mg/m^2,加生理盐水40ml,第1天静脉推注;长春花碱酰胺4mg/m^2加生理盐水40ml,第1、8天静脉推注;顺铂70～80mg/m^2加生理盐水1000ml,第1天静脉滴注。疗程1～4周期。中药组采用益气养阴软坚散结方,每日1剂。水煎2次,分2～3次服完,2个月为一疗程。中西医结合组用MVP方案加益气养阴软坚散结方,疗程是化疗1～4周期加中药2个月。结果:3组中,中西医结合治疗组总有效率最高(达83.3％),中药组为76.5％,化疗组为63.6％。中药组、中西医结合组治疗后体重增加和稳定及健康状况提高与稳定者明显多于化疗组。结论:中西医结合治疗老年晚期肺癌,比单纯应用化疗或中药治疗疗效好,并可减少化疗副反应,提高患者生存质量。

To compare the clinical efficacies of traditional Chinese medicine and/or chemotherapy in treating advanced lung cancer in elderly patients. Methods: One hundred and four aged patients with advanced lung cancer were randomly divided into three groups: the chemotherapy group(n=22) ,the traditional Chinese medicine group(n=34)and the combined therapy group (n = 48). The regimen of chemotherapy was MVP,each patient received one to four courses. The traditional Chinese medicine used decoction of herbs aimed at replenishing Qi and nourishing Yin, softening and dissipating hard nodes. The course of traditional Chinese medicine lasted two months. Results:The global effective rate of the combined therapy group (83. 3%) was superior to the traditional Chinese medicine group(76. 5%) ,and the effective rate of the latter group was again superior to that of chemotherapy group(63. 6%). The rates of weight gain or no weight loss in both traditional Chinese medicine group and the combined group were siginficantly higher than that of the chemotherapy group. Conclusion: The efficacy of traditional Chinese medicine together with chemotherapy in the treatment of advanced lung cancer in elderly was superior to traditional Chinese medicine alone or chemotherapy alone, and the combination possessed the advantages of decreasing the side effects of chemotherapy and increasing the quality of life of the patients.