培哚普利对充血性心力衰竭患者校正后QT离散度的影响

Effect of perindopril on QTcd in patients with congestive heart failure

观察培哚普利对充血性心力衰竭患者校正后QT离散度的影响。方法:选择确诊的充血性心力衰竭者42例,随机分为治疗组和对照组。对照组使用强心剂、利尿剂及对症治疗;治疗组在此基础上加用培哚普利4～8mg;疗程均为3～4周。于治疗前及治疗后进行QT离散度的测定。结果:治疗组治疗后QTcd明显低于治疗前,而对照组治疗前后QTcd无明显变化。结论:培哚普利能有效地缩短心肌复极化的离散程度,有利于患者心肌电活动一致和稳定。

To explore the effect of perindopril on QTcd in patients with congestive heart failure.Method: Forty-two patients with CHF were randomly allocated into treatment group (24 cases) and control group (18 cases). The patients in control group were given cardiotonics and diuretics and patients in treatment group were given in addition perindopril 4- 8mg/d. QTcd were measured before and after three weeks' treatment. Results: After three weeks' treatment, Qtcd of patients in treatment group decreased significantly as compared with pretreatment QTcd values. In patients of control group, there was no significant difference in QTcd before and after treaatment. Conclusion: Perindopril treatment results in the reduction of QTcd in patients with congestive heart failure.