低浓度混苯暴露对早早孕丢失的影响的初步研究

Preliminary study on effects of low concentration mixed benzene on female workers' early fetal loss

目的 探讨低浓度混苯暴露对早早孕丢失 (EFL)的影响。方法 选择某石化企业有混苯接触的女工 42人为暴露组、无混苯接触的女工 49人为内对照组、某化纤企业无混苯暴露的女工 118人为外对照组 ,自不采取避孕措施的第一个月经周期起留取每日晨尿 ,分别收集到 96、14 6和 435个周期共 15 0 84份尿样 ,用免疫放射法 (IRMA)测定尿液中人绒毛膜促性腺激素 (β hCG)的含量 ,并对早早孕丢失进行评价。 结果 三组女工EFL的发生率较接近 ,约为 30 %～40 % ,但暴露组和内对照组EFL的女工发生率及其周期发生率均高于外对照组 ,且暴露组和内对照组EFL阳性女工的周期发生率显著高于外对照组 (P <0 0 5 )。

Objective To study the effects of low concentrations mixed benzene exposure on early fetal loss (EFL) of female workers.Methods According to the executed standard, 42 women with mixed benzene exposure and 49 women without exposure were respectively selected as an exposure group and an internal control group in a large petrochemical corporation. In addition, 118 women in a large chemical fabric corporation were selected as an external control. The daily morning urines were collected at the beginning of the first menstrual cycle since no any contraception measures was taken. The total 15 084 urinary samples were collected respectively from 96, 146 and 435 cycles of the three groups. Then the urinary human chorionic gonadotropins (β hCG) were determined with immunoradiometric assay (IRMA) in order to evaluate EFL. Results The incidence rates (about 30%～40%) of EFL in three groups were closed to each other ,but incidence rates of EFL and their cycle rates from the female workers both in exposure group and in internal control group were higher than those in external control group, and the cycle rates of the women with EFL in exposure and internal control groups were higher than those in external control group ( P <0 05).Conclusion The present results suggested that the hazardous factors existed in the form of low concentration mixed benzene exposure in the petrochemical enterprise might result in EFL to some extents.