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周细胞在肾脏纤维化形成中作用的研究进展 被引量：5

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摘要 周细胞是一种血管壁细胞,位于微血管系统(毛细血管、毛细血管前微动脉、毛细血管后微静脉和集合细静脉)的内皮细胞基底膜侧。肾脏周细胞不完全包埋于毛细血管基底膜样物质中,与内皮细胞间存在榫-穴样接触。周细胞有多种起源,且它的体内识别还存在困难。研究表明周细胞和血管周围成纤维细胞是肌成纤维细胞的主要前体细胞,在肾脏纤维化形成中可能发挥重要的作用。周细胞与内皮细胞间存在许多信号传导通路,包括血小板衍生生长因子(PDGF)受体信号通路、血管内皮生长因子(VEGF)受体信号通路、Ang/Tie信号通路等。这些信号通路的提出为纤维化的治疗提供了新的治疗靶点。
作者 王静 刘必成
机构地区 东南大学肾脏病研究所附属中大医院肾脏科
出处 《东南大学学报（医学版）》 CAS 2013年第4期506-510,共5页 Journal of Southeast University(Medical Science Edition)
关键词 周细胞 内皮细胞 肌成纤维细胞 血小板衍生生长因子受体信号通路 血管内皮生长因子受体信号通路 文献综述
分类号 R692 [医药卫生—泌尿科学]
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参考文献23

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共引文献2

同被引文献80

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引证文献5

二级引证文献22

东南大学学报（医学版）
2013年 第4期

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