跨膜蛋白MS4A8B在前列腺癌组织中的表达及意义

The expression and clinical significance of MS4A8B in prostate cancer tissue

目的:探讨跨膜蛋白MS4A8B在前列腺癌组织中的表达及意义。方法:采用免疫组织化学检测140例临床局限性前列腺癌行前列腺癌根治术样本的组织微阵列芯片上的MS4A8B,并将MS4A8B与增殖指数(PCNA)和凋亡指数(TUNEL)进行相关性分析,将患者的年龄、PSA水平、Gleason评分及生化复发等临床病理特征与MS4A8B进行统计学处理。结果:良性组织、癌旁组织、前列腺上皮内瘤变、前列腺原发癌和前列腺转移淋巴结的MS4A8B蛋白表达分别为0%、1.94%、5.92%、62.6%和70.4%。Kaplan-Meier生存曲线分析表明前列腺癌组织高表达患者较低表达患者无生化复发生存时间(RFS)明显缩短(P<0.05);进一步研究发现MS4A8B蛋白表达与患者Gleason评分、增殖指数呈正相关(Spearman分析)(P<0.001)。结论:MS4A8B的表达与前列腺癌根治术后生化复发和转移相关,并在前列腺癌进展中扮演重要角色。

Objective：To clarify the expression and clinical significance of MS4A8B in prostate cancer. Meth- ods：In 140 clinically localized prostate cancer tissue samples undergoing radical prostatectomy, immunohistochemi- cal staining was performed. Statistical analysis was used to determine the correlation between MS4A8B and PCNA protein level as an index of proliferative activity, TUNEL staining as an index of apoptosis. We further analyzed statistically the value of the MS4A8B expression evaluating clinicopathological characteristics such as age, PSA at diagnosis, Gleason score, and biochemical recurrence. Results：Positive ratios of MS4A8B protein expression were 0%, 1. 940/00, 5.92%, 62.6% and 70.4% in benign, benign adjacent to prostate cancer, HPIN, primary and me- tastatic prostate cancer, respectively. Kaplan-Meier curves revealed that the recurrence--free survival （RFS） of the patients with high MS4A8B expression were shorter than that with low MS4A8B expression. Moreover, MS4A8B was positively associated with Gleason score, the proliferation index （all p~ 0. 001）. Conclusions： MS4A8B expression is associated with early biochemical relapse and metastasis after radical prostatectomy which plays an important role in progression of human prostate cancer