摘要
多系统萎缩(MSA)是一种散发的、迅速进展的神经系统变性疾病,临床表现为自主神经功能障碍和帕金森病样症状、小脑性共济失调的不同组合。对此疾病早期识别的研究进展导致了诊断标准的修订,包含首次将神经影像学特征列入诊断标准。例如MRI显示壳核、小脑中脚、脑桥、小脑萎缩;FDG-PET显示壳核、脑干、小脑代谢减退;SPECT或PET显示突触前黑质纹状体多巴胺能失神经支配。MSA的影像学特征可以作为临床生物学标记物用于早期识别MSA。
Multiple system atrophy（MSA） is a sporadic and rapidly progressive neurodegenerative disorder that presents with autonomic failure in combination with parkinsonism or cerebellar ataxia.Advances in the early recognition of this disease have resulted in revised diagnostic criteria,including neuroimaging features,such as atrophy of putamen,middle cerebellar peduncle,pons or cerebellum on magnetic resonance imaging（MRI）,hypometabolism in putamen,brainstem,or cerebellum on FDG-positron emission tomography（FDG-PET）,and presynaptic nigrostriatal dopaminergic denervation on single photon emission computerized tomography（SPECT） or PET.Neuroimaging can potentially be used as a clinical biomarker in the early diagnosis of MSA.
出处
《中国临床神经科学》
2013年第4期478-482,共5页
Chinese Journal of Clinical Neurosciences
基金
上海市首批青年医师培养资助计划(2012-2015年度)
