胚胎着床的调控机制

Regulatory mechanism of embryo implantation

胚胎着床是指具有着床能力的胚胎与接受态子宫之间建立联系的过程.胚胎着床是妊娠过程的主要限制步骤,女性不育症中75%是由着床失败引起的.研究着床过程的分子机制对于改善女性生殖能力,以及治疗不育和自发流产等相关疾病具有重要意义.随着基因表达谱分析及各种基因敲除小鼠模型的广泛应用,近年来关于着床分子机制的研究在很多方面取得了显著的进步.本文将综述近期胚胎着床领域的重要研究进展并探讨需要深入研究的问题.

Embryo implantation involves intricate communication between an active embryo and a receptive endometrium. It is a critical step in the establishment of pregnancy. About 75% of women exhibit infertility that is attributable to implantation failure. Deciphering the regulatory mechanisms of embryo implantation will be a significant advance toward reducing female infertility and treating fertility-related diseases. With the use of gene profile assays and knockout mice, much progress has been made in the field of embryo implantation over the past few years. Here we summarize the major progress that has been made in research on embryo implantation and explore directions for further study.