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Kennedy病一例 被引量:2

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摘要 1病例介绍患者男,62岁,因"四肢无力及肌肉萎缩10+年"于2011年3月收入我科。患者于1994年开始出现双下肢痛性痉挛和双侧乳房发育如女性,并伴有腹部肌肉不自主跳动。1999年患者出现下蹲后站立困难,逐渐缓慢加重,不能自行站立,持拐能缓慢步行。2005年患者出现双肩抬举困难,持握重物力量下降,以左侧为重,日常活动明显受影响,
出处 《华西医学》 CAS 2013年第7期1141-1142,共2页 West China Medical Journal
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  • 1Kennedy WR, Alter M. Progressive proximal spinal and bulbar muscular atrophy of late onset: a sex-linked recessive trait[J]. Neurology, 2000, 2(1): 3-5.
  • 2Guidetti D, Sabadini R, Ferlini A, et al. Epidemiological survey of X-linked bulbar and spinal muscular atrophy, or Kennedy disease, in the province of Reggio Emilia, Italy[J]. Eur J Epidemiol, 2001, 17(6): 587-591.
  • 3Montie HL, Merry DE. Autophagy and access: understanding the role of androgen receptor subcellular localization in SBMA[J]. Autophagy, 2009, 5(8): 1194-1197.
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  • 6Greenland KJ, Beilin J, Castro J, et al. Polymorphic CAG repeat length in the androgen receptor gene and association with neurodegeneration in a heterozygous female carrier of Kennedy's disease[J]. J Neurol, 2004, 251 (1): 35-41.
  • 7Atsuta N, Watanabe H, Ito M, et al. Natural history of spinal and bulbar muscular atrophy (SBMA): a study of 223 Japanese patients[J]. Brain, 2006, 129(6): 1446-1455.
  • 8Sperfeld AD, Karitzky J, Brummer D, et al. X-linked bulbospinal neuronopathy:Kennedy disease[J]. Arch Neurol, 2002, 59(12): 1921-1926.
  • 9Banno H, Katsuno M, Suzuki K, et al. Neuropathology and therapeutic intervention in spinal and bulbar muscular atrophy[J]. Int J Mol Sci, 2009, 10(3): 1000-1012.

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