摘要
目的探讨可降解镁合金吻合器应用于动物胃肠道吻合手术的可行性及安全性。方法将16只比格犬分为实验组及对照组,每组8只。实验组以镁合金吻合器进行吻合手术;对照组以钛合金吻合器进行吻合手术;每只比格犬均进行胃空肠及结肠两处吻合,比较两组间的吻合时间、手术后并发症、体质量变化、吻合口爆破压和血清镁离子浓度以及谷丙转氨酶、谷草转氨酶、尿素氮、肌酐浓度,观察镁合金吻合钉的降解情况,对比观察吻合口愈合及心、肝、肾、脑、脾的组织病理学标本。结果两组间吻合时间、手术后并发症、体质量变化、吻合口爆破压、镁离子浓度、肝。肾功能等差异均无统计学意义;组织病理学检查见吻合口愈合良好,无炎性细胞浸润;上述脏器的组织病理学检查未见明显差异,镁合金在吻合术后90d内可完全降解。结论镁合金吻合器进行胃肠道吻合手术安全可行,其降解过程对吻合口局部及其他重要脏器无不良影响,有望应用于人体胃肠道吻合手术中。
Objective To explore the safety and feasibility of biodegradable magnesium alloy stapler based on the result of animal experimental study for gastrointestinal anastomosis. Methods Sixteen beagle dogs were equally and randomly divided into experimental (magnesium alloy) group and control (titanium alloy) group. A gastrojejunal and a colonic anastomosis were performed in each beagle dog. The anastomosis time, postoperative complications, body weight, blasting pressure of anastomosis and serum glutamic pyruvic transaminase, glutamie oxaloacetic transaminase, creatinine, blood urea nitrogen, and serum magnesium were compared between the two groups. The healing of anastomosis and degradation of magnesium alloy were observed. The histopathological feasures of heart, liver, spleen and kidney were examined in the two groups. Results There were no significant differences in anastomosis time, body weight, postoperative complications, anastomotic bursting pressure between the two groups. The anastomosis was healed well, and no dramatic inflammatory cell infiltration was observed. Magnesium alloy could be degraded completely in the animal body within 90 days. There were no significant differences in serum glutamic pyruvic transaminase, gJutamic oxaloacetic transaminase, creatinine, blood urea nitrogen and serum magnesium between the two groups. Histopathological examination showed that the degradation of magnesium alloy did not harm the important organs(liver, kidney, heart, brain and spleen). Conclusions Magnesium alloy stapler is safe and feasible forgastrointestinal anastomosis in beagle dogs. The degradation of magnesium alloy does not harm the healing of anastomosis and other important organs. Magnesium alloy stapler may be a candidate of biodegradable and safe material of stapler for gastrointestinal anastomosis in human.
出处
《中华胃肠外科杂志》
CAS
CSCD
2013年第8期772-776,共5页
Chinese Journal of Gastrointestinal Surgery
关键词
胃肠道吻合
镁合金吻合器
动物实验
可行性
安全性
Gastrointestinal anastomosis
Magnesium alloy stapler
Animal study
Feasibility
Safety