植物中的蛋白质二硫键异构酶及其类蛋白

Protein Disulfide Isomerise and PDI-Like Proteins in Plant

蛋白质二硫键异构酶(protein disulfide isomerase,PDI)及其类蛋白,是硫氧还蛋白超家族的一员,具有催化蛋白质二硫键氧化、还原和异构的功能,并具有分子伴侣和抗分子伴侣活性及钙离子结合位点,在生物体内起着极其重要的作用。本文综述了近年来对植物PDILs的相关了解,总结了PDI类蛋白的结构、表达、定位、生化与生物学功能,也结合本实验室的工作,对水稻等PDI的相关信息与作用做了简要阐述,为加快这一重要酶及分子伴侣的研究提供启示。

Protein disulfide isomerase （PDI） and PDI-like proteins （PDILs）, belonging to thioredoxin （Trx） su- perfamily, have diverse functions in organisms. They can catalyze thiol-disulfide interchange, resulting in the formation, reduction, or isomerization of protein disulfide bonds in protein substrates. They also display chaper- one activity and anti-chaperone activity. Furthermore, they have CaZ＋-binding domain. Researches about PDI and PDILs from plant were summarized in this paper, including structure, expression, location, chemical func- tion and biological role. Related work by our research group about PDILs in rice was also presented. It may bring us a good insight for further research about this enzyme or chaperone with important roles.