Toll样受体在瘢痕疙瘩形成中的作用研究进展

Advances in the research of the effect of toll-like receptor in the formation of keloid

瘢痕疙瘩是皮肤损伤后的严重病理性改变，多发生于外伤、手术、感染及深度烧伤后。临床表现为超过损伤界限的持续性瘤样瘢痕增生，易造成局部畸形和功能障碍，且手术切除后极易复发，严重影响患者生活质量，头面部的瘢痕疙瘩更是给患者社交带来巨大的心理压力。瘢痕疙瘩的病因至今仍未明确，但作为天然免疫的模式识别受体之一，Toll样受体（TLR）在瘢痕疙瘩形成中发挥了重要作用，本文就相关研究进展进行综述。

Keloid is a kind of pathological scar of skin, which would seriously impair patient＇s quality of life. But until today, no reliable theory to explain the development of keloid has been established. Recent studies have found that toll-like re- ceptors plays an important role in the formation of keloid. This article reviews the advances in the research of toll-like receptors making contribution to the pathogenesis of keloid. Further re- searches could lead to a new strategy in treating keloid.