脑震荡患者血清中神经元特异性烯醇化酶与心理状况的相关性研究

Correlation between serum neuron specific enolase level and psychological status of patients with cerebral concussion

目的 探讨脑震荡患者血清中神经元特异性烯醇化酶（NSE）改变情况及其与患者心理状况变化之间的关系. 方法 选择江门市人民医院神经外科自2012年1月至12月收治的40例脑震荡患者作为脑震荡组,该院体检中心接收的40例健康体检者作为对照组.采用酶联免疫吸附法检测脑震荡组患者不同时期的血清中NSE的水平,并与对照组进行比较.采用90项症状自评量表（SCL-90）评定40例脑震荡组患者不同时期的SCL-90总分,并与全国常模进行比较.同时分析脑震荡组患者血清中不同时期NSE水平和SCL-90的关系. 结果 （1）伤后1d脑震荡组患者血清NSE水平明显高于对照组,差异有统计学意义（P＜0.05）；伤后3d和7d脑震荡患者血清NSE水平接近正常,与对照组比较差异无统计学意义（P＞0.05）.（2）脑震荡患者伤后1d、3d及7 d SCL-90评分均显著高于全国常模,差异有统计学意义（P＜0.05）.（3）伤后第1、3天脑震荡患者血清NSE水平与SCL-90评分呈正相关（r=0.498,P=0.001；r=0.418,P=0.007）.伤后第7天脑震荡患者血清NSE水平与SCL-90评分无相关性（r=0.213,P=0.186）. 结论 脑震荡患者不同时期的血清中NSE水平与SCL-90总分具有不同的相关性,联合应用有利于脑震荡患者的诊治.

Objective To study the correlation between the changes of serum neuron specific enolase （NSE） level and psychological statuses in patients with cerebral concussion.Methods Forty patients with cerebral concussion,admitted to our hospital from January 2012 to December 2012,were chosen in our study as experimental group,and other 40 healthy controls performed physical examination in our Physical Examination Center at the same period were chosen.The serum NSE level in the two groups was determined by enzyme-linked immunosorbent assay （ELISA）; Symptom Checklist 90 （SCL-90） scale was performed in 40 patients at different times after injury,and these data were compared with those from the national norm; the correlation between the changes of serum NSE level and SCL-90 scores was analyzed.Results The serum NSE level in the experimental group 1 d after the injury was obviously higher than that in the control group （P〈0.05）; 3 and 7 d after the injury,the serum NSE level in the experimental group was close to normal level,which showed no significant differece as compared with that in the control group （P〉0.05）.The SCL-90 scores in the experiemtal group 1,3 and 7 d after injury was signficantly higher than that of the national norm （P〈0.05）.Positive corelation was noted between serum NSE level and SCL-90 scores 1 and 3 d after injury （r=0.498,P=0.001; r=0.418,P=0.007）;however,negative corelation was noted btween the two 7 d after injury （r=0.213,P=0.186）.Conclusion Different corelation can be noted between serum NSE level and SCL-90 scores at different time points;combined application of serum NSE level and SCL-90 scores can promote the diagnosis and treatment of patients with brain concussion.