超声与核磁共振在诊断新生儿胼胝体发育不全中的比较

Ultrasonography and magnetic resonance imaging for diagnosis of neonatal agenesis of the corpus callosum:a comparative study

目的总结新生儿胼胝体发育不全的超声表现,提高超声检查在新生儿胼胝体发育不全中的应用价值。方法对2010年6月~2012年12月在广州市妇女儿童医疗中心儿童院区新生儿监护室住院的8563例新生儿进行常规颅脑超声筛查,共检出胼胝体发育不全37例,与MRI比较,评价超声检查的准确性。结果 37例新生儿中超声对胼胝体完全缺如、部分缺如的诊断敏感性分别为100%和90%,特异性分别为90.9%和94.1%,准确性分别为94.6%和91.9%。与MRI的Kappa值分别为：0.890和0.837。二者的一致率为91%。结论超声检查与MRI对诊断新生儿胼胝体发育不全具有高度一致性,因此对新生儿胼胝体结构异常的全面透彻理解以及掌握准确的超声表现将使胼胝体发育不良的诊断更加精确。

Objective To summarize the ultrasonoscopic features of neonate corpus callosum agenesis for better diagnosis of this condition.Methods A total of 8563 neonates were screened by cerebral ultrasound in neonate care unit of our hospital from June 2010 to December 2012,and 37 cases of agenesis of the corpus callosum were identified.The diagnostic accuracy of ultrasonography and magnetic resonance imaging(MRI) for this condition was evaluated.Results The sensitivity,specificity,and accuracy of ultrasound diagnosis for complete and incomplete absence of neonate corpus callosum were 100% and 90%,90.9% and 94.1%,94.6% and 91.9% in the 37 cases,respectively.The Kappa value of ultrasonography and MRI were 0.890 and 0.837,with a consistent rate of 91%.Conclusion Ultrasonography and MRI show a high consistency in the diagnosis of neonatal agenesis of the corpus callosum.