氟尿嘧啶类药物的性味辨析初探

Nature and flavor of 5-fluorouracil: a TCM perspective

通过辨析化疗药物的性味,有望让化疗药物与中医体系融合并丰富中药学的内容,也可能为个体化应用化疗药物提供新的思路。我们据中医理论及氟尿嘧啶类药物在人体的反应,通过辨析和口尝,结合当前中药减毒领域内的新成果,确认氟尿嘧啶类药物为苦、辛,大热,有毒之品。未来的研究需要观察虚寒体质和阳热体质的患者在疗效和副作用上可能存在的不同。

By analyzing the properties （nature and ftavour） of chemotherapy drugs from a perspective of traditional Chinese medicine （TCM）, this article aims to integrate chemotherapy drugs with the TCM system and expects to enrich the content of Chinese Herbology and provide new ideas for individualized application of chemotherapy drugs as well. On the basis of TCM theory and the responses of 5-fluorouracil in human, we analyzed and tasted 5-fluorouracil in consideration of the current achievements in the field of toxicity reduction of Chinese herbs, and recognized that 5-ftuorouracil is bitter and pungent in flavor, hot and toxic in nature. Our future study will focus on observing the possible differences in efficacy and side-effect in patients with asthenia cold syndromes and those presenting Yang-heat syndromes.